Aartjan Te Velthuis

First name

Aartjan

Last name

Te Velthuis

French, Hollie, Emmanuelle Pitré, Michael Oade, Elizaveta Elshina, Karishma Bisht, Alannah King, David Bauer, and Aartjan Te Velthuis. (2022) 2022. “Transient RNA Structures Cause Aberrant Influenza Virus Replication and Innate Immune Activation”. Sci Adv 8 (36): eabp8655. doi:10.1126/sciadv.abp8655.

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Bisht, Karishma, and Aartjan Te Velthuis. (2022) 2022. “Decoding the Role of Temperature in RNA Virus Infections”. MBio, e0202122. doi:10.1128/mbio.02021-22.

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Pitre, Emmanuelle, and Aartjan Te Velthuis. (2022) 2022. “Tinker, Tailor, Antiviral: RNA Virus Inhibition by Induced Recombination”. Trends Biochem Sci. doi:10.1016/j.tibs.2022.01.003.

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Nilsson-Payant, Benjamin, , and Aartjan Te Velthuis. (2021) 2021. “The Host Factor ANP32A Is Required for Influenza A Virus VRNA and CRNA Synthesis”. J Virol, jvi0209221. doi:10.1128/jvi.02092-21.

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Alnaji, Fadi, William Reiser, Joel Rivera-Cardona, Aartjan Te Velthuis, and Christopher Brooke. (2021) 2021. “Influenza A Virus Defective Viral Genomes Are Inefficiently Packaged into Virions Relative to Wild-Type Genomic RNAs”. MBio, e0295921. doi:10.1128/mBio.02959-21.

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Pitre, Emmanuelle, and Aartjan Te Velthuis. 2021. “Understanding Viral Replication and Transcription Using Single-Molecule Techniques”. Enzymes 49: 83-113. doi:10.1016/bs.enz.2021.07.005.

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Elshina, Elizaveta, and Aartjan Te Velthuis. (2021) 2021. “The Influenza Virus RNA Polymerase As an Innate Immune Agonist and Antagonist”. Cell Mol Life Sci. doi:10.1007/s00018-021-03957-w.

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Elli, Stefano, Denisa Bojkova, Marco Bechtel, Thomas Vial, David Boltz, Miguel Muzzio, Xinjian Peng, et al. (2021) 2021. “Enisamium Inhibits SARS-CoV-2 RNA Synthesis”. Biomedicines 9 (9). doi:10.3390/biomedicines9091254.

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Gopal, Vikram, Benjamin Nilsson-Payant, Hollie French, Jurre Siegers, Wai-Shing Yung, Matthew Hardwick, and Aartjan Te Velthuis. (2021) 2021. “Zinc-Embedded Polyamide Fabrics Inactivate SARS-CoV-2 and Influenza A Virus”. ACS Appl Mater Interfaces 13 (26): 30317-25. doi:10.1021/acsami.1c04412.

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Weis, Sabrina, and Aartjan Te Velthuis. (2021) 2021. “Influenza Virus RNA Synthesis and the Innate Immune Response”. Viruses 13 (5). doi:10.3390/v13050780.

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Te Velthuis, Aartjan, Tatiana Zubkova, Megan Shaw, Andrew Mehle, David Boltz, Norbert Gmeinwieser, Holger Stammer, Jens Milde, Lutz Müller, and Victor Margitich. (2021) 2021. “Enisamium Reduces Influenza Virus Shedding and Improves Patient Recovery by Inhibiting Viral RNA Polymerase Activity”. Antimicrob Agents Chemother. doi:10.1128/AAC.02605-20.

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Te Velthuis, Aartjan, Philippe Sakalis, Donald Fowler, and Christoph Bagowski. (2011) 2011. “Genome-Wide Analysis of PDZ Domain Binding Reveals Inherent Functional Overlap Within the PDZ Interaction Network”. PLoS One 6 (1): e16047. doi:10.1371/journal.pone.0016047.

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Ott, Elisabeth, Nynke Akker, Philippe Sakalis, Adriana Gittenberger-de Groot, Aartjan Te Velthuis, and Christoph Bagowski. (2008) 2008. “The Lim Domain Only Protein 7 Is Important in Zebrafish Heart Development”. Dev Dyn 237 (12): 3940-52. doi:10.1002/dvdy.21807.

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Te Velthuis, Aartjan, Jeroen Admiraal, and Christoph Bagowski. (2007) 2007. “Molecular Evolution of the MAGUK Family in Metazoan Genomes”. BMC Evol Biol 7: 129. doi:10.1186/1471-2148-7-129.

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Te Velthuis, Aartjan, Tadamoto Isogai, Lieke Gerrits, and Christoph Bagowski. (2007) 2007. “Insights into the Molecular Evolution of the PDZ LIM Family and Identification of a Novel Conserved Protein Motif”. PLoS One 2 (2): e189. doi:10.1371/journal.pone.0000189.

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Ott, Elisabeth, Aartjan Te Velthuis, and Christoph Bagowski. (2007) 2007. “Comparative Analysis of Splice Form-Specific Expression of LIM Kinases During Zebrafish Development”. Gene Expr Patterns 7 (5): 620-9. doi:10.1016/j.modgep.2006.12.005.

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Te Velthuis, Aartjan, Elisabeth Ott, Ines Marques, and Christoph Bagowski. (2007) 2007. “Gene Expression Patterns of the ALP Family During Zebrafish Development”. Gene Expr Patterns 7 (3): 297-305. doi:10.1016/j.modgep.2006.09.001.

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Te Velthuis, Aartjan, Jonathan Grimes, and Ervin Fodor. (2021) 2021. “Structural Insights into RNA Polymerases of Negative-Sense RNA Viruses”. Nat Rev Microbiol. doi:10.1038/s41579-020-00501-8.

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Te Velthuis, Aartjan, Nicole Robb, Achillefs Kapanidis, and Ervin Fodor. (2016) 2016. “The Role of the Priming Loop in RNA Synthesis”. Nat Microbiol 1 (5). doi:10.1038/nmicrobiol.2016.29.

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Walker, Alexander, Haitian Fan, Jeremy Keown, Victor Margitich, Jonathan Grimes, Ervin Fodor, and Aartjan Te Velthuis. (2020) 2020. “Enisamium Is a Small Molecule Inhibitor of the Influenza A Virus and SARS-CoV-2 RNA Polymerases”. BioRxiv. doi:10.1101/2020.04.21.053017.

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Knoops, Kèvin, Cindy Swett-Tapia, Sjoerd Worm, Aartjan Te Velthuis, Abraham Koster, Mieke Mommaas, Eric Snijder, and Marjolein Kikkert. (2010) 2010. “Integrity of the Early Secretory Pathway Promotes, But Is Not Required For, Severe Acute Respiratory Syndrome Coronavirus RNA Synthesis and Virus-Induced Remodeling of Endoplasmic Reticulum Membranes”. J Virol 84 (2): 833-46. doi:10.1128/JVI.01826-09.

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Ossevoort, Martine, Arnaud Zaldumbide, Aartjan Te Velthuis, Mark Melchers, Maaike Ressing, Emmanuel Wiertz, and Rob Hoeben. (2007) 2007. “The Nested Open Reading Frame in the Epstein-Barr Virus Nuclear Antigen-1 MRNA Encodes a Protein Capable of Inhibiting Antigen Presentation in Cis”. Mol Immunol 44 (14): 3588-96. doi:10.1016/j.molimm.2007.03.005.

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Adedeji, Adeyemi, Bruno Marchand, Aartjan Te Velthuis, Eric Snijder, Susan Weiss, Robert Eoff, Kamalendra Singh, and Stefan Sarafianos. 2012. “Mechanism of Nucleic Acid Unwinding by SARS-CoV Helicase”. PLoS One 7 (5): e36521. doi:10.1371/journal.pone.0036521.

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Te Velthuis, Aartjan, Lauren Turrell, Frank Vreede, and Ervin Fodor. (2013) 2013. “Uncoupling of Influenza A Virus Transcription and Replication through Mutation of the Unpaired Adenosine in the Viral RNA Promoter”. J Virol 87 (18): 10381-4. doi:10.1128/JVI.00636-13.

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Paterson, Duncan, Aartjan Te Velthuis, Frank Vreede, and Ervin Fodor. (2014) 2014. “Host Restriction of Influenza Virus Polymerase Activity by PB2 627E Is Diminished on Short Viral Templates in a Nucleoprotein-Independent Manner”. J Virol 88 (1): 339-44. doi:10.1128/JVI.02022-13.

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Stubbs, Thomas, and Aartjan Te Velthuis. (2014) 2014. “The RNA-Dependent RNA Polymerase of the Influenza A Virus”. Future Virol 9 (9): 863-76. doi:10.2217/fvl.14.66.

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Nilsson, Benjamin, Aartjan Te Velthuis, and Ervin Fodor. (2017) 2017. “Role of the PB2 627 Domain in Influenza A Virus Polymerase Function”. J Virol 91 (7). doi:10.1128/JVI.02467-16.

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Posthuma, Clara, Aartjan Te Velthuis, and Eric Snijder. (2017) 2017. “Nidovirus RNA Polymerases: Complex Enzymes Handling Exceptional RNA Genomes”. Virus Res 234: 58-73. doi:10.1016/j.virusres.2017.01.023.

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Te Velthuis, Aartjan, Jason Long, and Wendy Barclay. 2018. “Assays to Measure the Activity of Influenza Virus Polymerase”. Methods Mol Biol 1836: 343-74. doi:10.1007/978-1-4939-8678-1_17.

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Russell, Alistair, Elizaveta Elshina, Jacob Kowalsky, Aartjan Te Velthuis, and Jesse Bloom. (2019) 2019. “Single-Cell Virus Sequencing of Influenza Infections That Trigger Innate Immunity”. J Virol 93 (14). doi:10.1128/JVI.00500-19.

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Te Velthuis, Aartjan, and Ervin Fodor. (2016) 2016. “Influenza Virus RNA Polymerase: Insights into the Mechanisms of Viral RNA Synthesis”. Nat Rev Microbiol 14 (8): 479-93. doi:10.1038/nrmicro.2016.87.

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Te Velthuis, Aartjan. (2014) 2014. “Common and Unique Features of Viral RNA-Dependent Polymerases”. Cell Mol Life Sci 71 (22): 4403-20. doi:10.1007/s00018-014-1695-z.

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Te Velthuis, Aartjan, Sjoerd Worm, and Eric Snijder. (2012) 2012. “The SARS-Coronavirus nsp7+nsp8 Complex Is a Unique Multimeric RNA Polymerase Capable of Both De Novo Initiation and Primer Extension”. Nucleic Acids Res 40 (4): 1737-47. doi:10.1093/nar/gkr893.

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Te Velthuis, Aartjan, Sjoerd Worm, Amy Sims, Ralph Baric, Eric Snijder, and Martijn Hemert. (2010) 2010. “Zn(2+) Inhibits Coronavirus and Arterivirus RNA Polymerase Activity in Vitro and Zinc Ionophores Block the Replication of These Viruses in Cell Culture”. PLoS Pathog 6 (11): e1001176. doi:10.1371/journal.ppat.1001176.

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Te Velthuis, Aartjan, Jacob Kerssemakers, Jan Lipfert, and Nynke Dekker. (2010) 2010. “Quantitative Guidelines for Force Calibration through Spectral Analysis of Magnetic Tweezers Data”. Biophys J 99 (4): 1292-302. doi:10.1016/j.bpj.2010.06.008.

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Te Velthuis, Aartjan, Jamie Arnold, Craig Cameron, Sjoerd Worm, and Eric Snijder. (2010) 2010. “The RNA Polymerase Activity of SARS-Coronavirus nsp12 Is Primer Dependent”. Nucleic Acids Res 38 (1): 203-14. doi:10.1093/nar/gkp904.

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Holubovska, Olha, Denisa Bojkova, Stefano Elli, Marco Bechtel, David Boltz, Miguel Muzzio, Xinjian Peng, et al. (2021) 2021. “Enisamium Is an Inhibitor of the SARS-CoV-2 RNA Polymerase and Shows Improvement of Recovery in COVID-19 Patients in an Interim Analysis of a Clinical Trial”. MedRxiv. doi:10.1101/2021.01.05.21249237.

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Te Velthuis, Aartjan. (2019) 2019. “Flu Transcription Captured in Action”. Nat Struct Mol Biol 26 (6): 393-95. doi:10.1038/s41594-019-0243-9.

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Fodor, Ervin, and Aartjan Te Velthuis. (2020) 2020. “Structure and Function of the Influenza Virus Transcription and Replication Machinery”. Cold Spring Harb Perspect Med 10 (9). doi:10.1101/cshperspect.a038398.

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Robb, Nicole, Aartjan Te Velthuis, Ervin Fodor, and Achillefs Kapanidis. (2019) 2019. “Real-Time Analysis of Single Influenza Virus Replication Complexes Reveals Large Promoter-Dependent Differences in Initiation Dynamics”. Nucleic Acids Res 47 (12): 6466-77. doi:10.1093/nar/gkz313.

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Goldhill, Daniel, Aartjan Te Velthuis, Robert Fletcher, Pinky Langat, Maria Zambon, Angie Lackenby, and Wendy Barclay. (2018) 2018. “The Mechanism of Resistance to Favipiravir in Influenza”. Proc Natl Acad Sci U S A 115 (45): 11613-18. doi:10.1073/pnas.1811345115.

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Te Velthuis, Aartjan, Joshua Long, David Bauer, Rebecca Fan, Hui-Ling Yen, Jane Sharps, Jurre Siegers, et al. (2018) 2018. “Mini Viral RNAs Act As Innate Immune Agonists During Influenza Virus Infection”. Nat Microbiol 3 (11): 1234-42. doi:10.1038/s41564-018-0240-5.

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Te Velthuis, Aartjan, and Judith Oymans. (2018) 2018. “Initiation, Elongation, and Realignment During Influenza Virus MRNA Synthesis”. J Virol 92 (3). doi:10.1128/JVI.01775-17.

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Oymans, Judith, and Aartjan Te Velthuis. (2018) 2018. “A Mechanism for Priming and Realignment During Influenza A Virus Replication”. J Virol 92 (3). doi:10.1128/JVI.01773-17.

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Robb, Nicole, Aartjan Te Velthuis, Ralph Wieneke, Robert Tampé, Thorben Cordes, Ervin Fodor, and Achillefs Kapanidis. (2016) 2016. “Single-Molecule FRET Reveals the Pre-Initiation and Initiation Conformations of Influenza Virus Promoter RNA”. Nucleic Acids Res 44 (21): 10304-15. doi:10.1093/nar/gkw884.

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Te Velthuis, Aartjan, Nicole Robb, Achillefs Kapanidis, and Ervin Fodor. (2016) 2016. “The Role of the Priming Loop in Influenza A Virus RNA Synthesis”. Nat Microbiol 1: 16029. doi:10.1038/nmicrobiol.2016.29.

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