@article{179231,
  keywords = {Promoter Regions, Genetic, RNA, Viral, Transcription, Genetic, Protein Binding, Virus Replication, Adenosine, Point Mutation, Influenza A virus, RNA-Dependent RNA Polymerase},
  author = {Aartjan Te Velthuis and Lauren Turrell and Frank Vreede and Ervin Fodor},
  title = {Uncoupling of influenza A virus transcription and replication through mutation of the unpaired adenosine in the viral RNA promoter},
  abstract = { Transcription and replication of the influenza A virus RNA genome are mediated by the viral RNA polymerase from a promoter consisting of the partially base-paired 3{\textquoteright} and 5{\textquoteright} termini of viral genome segments. Here we show that transcription and replication can be uncoupled by mutation of an unpaired adenosine in the 5{\textquoteright} strand of the promoter. This residue is important for transcription but not replication by being essential for the cap-binding activity of the RNA polymerase.  },
  year = {2013},
  journal = {J Virol},
  volume = {87},
  pages = {10381-4},
  month = {09/2013},
  issn = {1098-5514},
  doi = {10.1128/JVI.00636-13},
  language = {eng},
}